Mutation frequency

Mutation frequency and mutation rates are highly correlated to each other. Tests for mutation frequency are cost effective in laboratories ^[1] however; these two concepts provide vital information in reference to accounting for the emergence of mutations on any given germ line.^[2]^[3]

There are several tests utilized in measuring the chances of mutation frequency and rates occurring in a particular gene pool. Some of the test are as follows:

Avida Digital Evolution Platform ^[4]
Fluctuation Analysis ^[5]

Mutation frequency and rate provide information about how often a mutation may be expressed in a particular genetic group or sex.^[6] For example, Yoon et al. (2009), suggested that there were higher sperm mutation frequencies in sperm from older donors. This suggests that males can contribute to genetic disorders of X-linked recessive chromosomes.^[7] Evolutionary influences affect mutation frequency and rate. Analyzing the mutation frequency and rates of a particular species may provide a way to understand the genetic component of its longevity ^[5]

References

↑ Araten, D., Golde, D., Zhang, R., Taler, H., Gargiulo, L., Notaro, G., & Luzzatto, L. (2005). A quantitative measurement for the human somatic mutation rate. Cancer Research, (65), 8111-8117.
↑ Peruzzi, B., Araten, D., Notaro, R., & Luzzatto, L. (2009). The use of pig-a as a sentinel gene for the study of the somatic mutation rate and the mutagenic agents in vivo. Mutation Research, (705), 3-10.
↑ Peruzzi, B., Araten, D., Notaro, R., & Luzzatto, L. (2009). The use of pig-a as a sentinel gene for the study of the somatic mutation rate and the mutagenic agents in vivo. Mutation Research, (705), 3-10.described mutation frequency as containing a segment of cells that includes a mutation within particular trait, and the authors defined mutation rates as being chances an innovative alteration will take place in hereditary trait due to cell division.
↑ Clune, J., Misevic, D., Ofria, C., Lenski, R., Elena, S. F., & Sanjuan, R. (2008). Natural selection fails to optimize mutation rates for long-term adaptation on rugged fitness landscapes. Computational Biology, 4(9), 1-8.
1 2 Nishant, K., Singh, N., & Alani, E. (2009). Genomic mutation rates: what high-throughput methods can tell us. Bioessays, 31(9), 912-920.
↑ Yoon, S., Qin, J., Glaser, R., Jabs, E., Wexler, N., Sokol, R., Arnheim, N., & Calabrese, P. (2009). The ups and downs of mutation frequencies during aging can account for the apert syndrome paternal age effect. PLos Genetics, 5(7), 1-19.
↑ http://users.rcn.com./jkimball.ma.ultranet/BiologyPages/M/Mutations.html(http://users.rcn.com./jkimball.ma.ultranet/BiologyPages/M/Mutations.html) ^{[dead link]}
1 2 Hill KA, Halangoda A, Heinmoeller PW, Gonzalez K, Chitaphan C, Longmate J, Scaringe WA, Wang JC, Sommer SS. Tissue-specific time courses of spontaneous mutation frequency and deviations in mutation pattern are observed in middle to late adulthood in Big Blue mice. Environ Mol Mutagen. 2005 Jun;45(5):442-54. doi: 10.1002/em.20119. PMID 15690342
↑ Stuart GR, Oda Y, Boer JG, Glickman BW. No change in spontaneous mutation frequency or specificity in dietary restricted mice. Carcinogenesis. 2000 Feb;21(2):317-9. doi: 10.1093/carcin/21.2.317. PMID 10657975

Mutation frequency

See also

References

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