Azzopardi broke her own national record in the 200 metre individual medley at the 2018 International Ströck ATUS Graz Trophy.[3] Then at the 2018 World Short-Course Championships, she finished 42nd in the 200 metre freestyle,[4] 32nd in the 200 metre individual medley,[5] and 27th with the Maltese mixed 4 × 50 metre medley relay team.[6]
At the 2019 Games of the Small States of Europe, Azzopardi won bronze medals in the 200 metre individual medley with a new national record, the 4 × 100 metre freestyle relay, and the 4 × 200 metre freestyle relay.[7][8] She then represented Malta at the 2019 World Aquatics Championships in the 100 metre freestyle and 200 metre individual medley, finishing 55th and 32nd, respectively.[9][10]
Azzopardi competed at the 2020 European Championships and finished 56th in the 200 metre freestyle with a new national record,[11] 61st in the 100 metre freestyle,[12] and 36th in the 200 metre individual medley.[13] At the 2021 International Turkcell Open, she broke the national record in the 200 metre freestyle in the heats and broke it again in the finals.[14]
Azzopardi joined San Jose State University's swimming team in 2022.[15] At the 2023 Games of the Small States of Europe, she helped the Maltese 4 × 200 metre freestyle relay team break the national record and win the silver medal.[16] She then helped the 4 × 100 metre freestyle relay team also break the national record and win a bronze medal.[17] She then represented Malta at the 2023 World Aquatics Championships and finished 42nd and 54th in the 100 and 200 metre freestyle events, respectively.[18][19]