N-(2-Cyanoethyl)tryptamine

N-(2-Cyanoethyl)tryptamine (CE-T) is a serotonin receptor modulator and possible psychedelic drug of the tryptamine family related to tryptamine (T).^[1][2][3][4] It is the N-(2-cyanoethyl) derivative of tryptamine.^[1][2][3][4]

Other namesN-2-Cyanoethyltryptamine; N-Cyanoethyltryptamine; CE-T; CET

Drug classSerotonin receptor agonist; Monoamine releasing agent

ATC code

• None

CAS Number

• 105115-85-3

Quick facts Clinical data, Other names ...

N-(2-Cyanoethyl)tryptamine

Clinical data
Other names	N-2-Cyanoethyltryptamine; N-Cyanoethyltryptamine; CE-T; CET
Drug class	Serotonin receptor agonist; Monoamine releasing agent
ATC code	None
Identifiers
IUPAC name 3-[2-(1H-indol-3-yl)ethylamino]propanenitrile
CAS Number	105115-85-3
PubChem CID	53876738
ChemSpider	28686048
Chemical and physical data
Formula	C13H15N3
Molar mass	213.284 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1=CC=C2C(=C1)C(=CN2)CCNCCC#N
InChI InChI=1S/C13H15N3/c14-7-3-8-15-9-6-11-10-16-13-5-2-1-4-12(11)13/h1-2,4-5,10,15-16H,3,6,8-9H2 Key:HGYHTHWLJDVNPB-UHFFFAOYSA-N

Close

The drug acts as a prodrug of tryptamine and hence is a non-selective serotonin receptor agonist and monoamine releasing agent similarly.^[1][2][3][4] It shows greatly sustained tryptamine levels and neurochemical effects in rodents compared to tryptamine itself however.^[3][1][4][2] Peak levels of tryptamine with CE-T in the brain were lower than tryptamine itself, whereas total exposure to tryptamine with CE-T in the brain was no different than with tryptamine itself in rodents.^[3] CE-T alters brain serotonin and dopamine levels similarly to tryptamine, whereas both drugs have limited effects on brain norepinephrine levels.^[3] It produces hypolocomotion in rodents similarly to the combination of tryptamine with a monoamine oxidase inhibitor (MAOI).^[4] However, whereas tryptamine was unable to produce hypolocomotion without an MAOI, CE-T showed hypolocomotion regardless of whether the MAOI clorgiline was co-administered.^[4]

CE-T was first described in the scientific literature by 1985.^[2][3][1][4]