N-Acetylcysteine ethyl ester

Drug classAntioxidant

CAS Number

• 59587-09-6

PubChem CID

• 148861

ChemSpider

• 131213

N-Acetylcysteine ethyl ester

Clinical data
Drug class	Antioxidant
Identifiers
IUPAC name ethyl (2R)-2-acetamido-3-sulfanylpropanoate
CAS Number	59587-09-6
PubChem CID	148861
ChemSpider	131213
UNII	HT8ACS9ZPT
ChEMBL	ChEMBL5435500
CompTox Dashboard (EPA)	DTXSID80208249
Chemical and physical data
Formula	C7H13NO3S
Molar mass	191.25 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCOC(=O)[C@H](CS)NC(=O)C
InChI InChI=1S/C7H13NO3S/c1-3-11-7(10)6(4-12)8-5(2)9/h6,12H,3-4H2,1-2H3,(H,8,9)/t6-/m0/s1 Key:MSMRAGNKRYVTCX-LURJTMIESA-N

N-Acetylcysteine ethyl ester (NACET, NAC-Et) is an antioxidant which acts as a lipophilic prodrug for N-acetylcysteine and subsequently glutathione, with improved bioavailability over N-acetylcysteine itself, and has been researched in animal studies as a potential treatment for diabetic retinopathy.^{[1][2][3][4][5]} It has also been sold as a "dietary supplement" in combination with glycine under the name GlyNAC-Et as a supposedly improved version of the older glycine-NAC combination GlyNAC which has been claimed to show efficacy in counteracting symptoms associated with aging as well as HIV infection, diabetes and nerve damage.^{[6][7][8][9][10][11][12]} Several related compounds such as γ-glutamylcysteine ethyl ester and glutathione ethyl ester have been investigated for similar applications.^[13][14][15]