N-Desalkylflurazepam
Benzodiazepine analog
From Wikipedia, the free encyclopedia
N-Desalkylflurazepam (also known as norflurazepam) is a benzodiazepine analog and an active metabolite of several other benzodiazepine drugs including flurazepam,[5] flutoprazepam,[6] fludiazepam,[7] midazolam,[8] flutazolam,[9] quazepam,[10] and ethyl loflazepate.[11][12] It is long-acting, prone to accumulation,[10][3] and binds unselectively to the various benzodiazepine receptor subtypes.[10] It has been sold as a designer drug from 2016 onward.[13]
- CA: Schedule IV
- DE: NpSG (Industrial and scientific use only)
- UK: Under Psychoactive Substances Act
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| Routes of administration | By mouth |
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| Bioavailability | Peak plasma concentration achieved within 90-120 minutes |
| Metabolism | Liver |
| Elimination half-life | 47-150 hours[1] (~71hr avg)[2] 150-200 hours (under continuous administration)[3] |
| Excretion | Kidney |
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| ECHA InfoCard | 100.018.863 |
| Chemical and physical data | |
| Formula | C15H10ClFN2O |
| Molar mass | 288.71 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 205 to 206 °C (401 to 403 °F) [4] |
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Pharmacology
Pharmacokinetics
N-Desalkylflurazepam has an elimination half-life of 47–150 hours[1] (up to 200 hours in some healthy volunteers),[3] with an average of ~71 hours.[2] Peak blood concentrations of N-Desalkylflurazepam is reached at 10.2 h following a single 15 mg dose of Flurazepam, typically around ~10-20.4 ng/mL.[2][3]
Its plasma levels are unreliable amongst patients, and are largely influenced by liver disease, liver enzyme inducers and inhibitors, as well as old age (in men).[3]
