N-Acetylaspartic acid

Derivative of aspartic acid found in the brain From Wikipedia, the free encyclopedia

N-Acetylaspartic acid, or N-acetylaspartate (NAA), is a derivative of aspartic acid with a formula of C6H9NO5 and a molecular weight of 175.139.

Quick facts Names, Identifiers ...
N-Acetylaspartic acid
Stereo, skeletal formula of N-acetylaspartic acid (S)
Stereo, skeletal formula of N-acetylaspartic acid (S)
Names
IUPAC name
2-Acetamidobutanedioic acid[1]
Identifiers
3D model (JSmol)
1726198 S
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.012.403 Edit this at Wikidata
EC Number
  • 219-827-5
KEGG
MeSH N-acetylaspartate
RTECS number
  • CI9098600
UNII
  • InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12) X markN
    Key: OTCCIMWXFLJLIA-UHFFFAOYSA-N X markN
  • CC(=O)N[C@@H](CC(=O)O)C(=O)O
Properties
C6H9NO5
Molar mass 175.140 g·mol−1
Appearance Colourless, transparent crystals
Melting point 137 to 140 °C (279 to 284 °F; 410 to 413 K)
Boiling point 141 to 144 °C (286 to 291 °F; 414 to 417 K)
log P −2.209
Acidity (pKa) 3.142
Basicity (pKb) 10.855
Hazards
GHS labelling:
GHS07: Exclamation mark
Warning
H315, H319, H335
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
Related compounds
Related alkanoic acids
Related compounds
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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NAA is the second-most-concentrated molecule in the brain after the amino acid glutamate. It is detected in the adult brain in neurons,[2] oligodendrocytes and myelin[3] and is synthesized in the mitochondria from the amino acid aspartic acid and acetyl-coenzyme A.[4]

Function

The various functions served by NAA are under investigation, but the primary proposed functions include:

  • Neuronal osmolyte that is involved in fluid balance in the brain
  • Source of acetate for lipid and myelin synthesis in oligodendrocytes, the glial cells that myelinate neuronal axons
  • Precursor for the synthesis of the neuronal dipeptide N-Acetylaspartylglutamate
  • Contributor to energy production from the amino acid glutamate in neuronal mitochondria.

In the brain, NAA was thought to be present predominantly in neuronal cell bodies, where it acts as a neuronal marker,[5] but it is also free to diffuse throughout neuronal fibers.[6]

Applications

However, the recent discovery of a higher concentration of NAA in myelin and oligodendrocytes than in neurons raises questions about the validity of the use of NAA as a neuronal marker.[3] NAA gives off the largest signal in magnetic resonance spectroscopy of the human brain. The levels measured there are decreased in numerous neuropathological conditions ranging from brain injury to stroke to Alzheimer's disease. This fact makes NAA a potential diagnostic molecule for doctors treating patients with brain damage or disease.

NAA may be a marker of creativity.[7] High NAA levels in the hippocampus are related to better working memory performance in humans.[8] Whole-brain levels of NAA have also been found to be positively correlated with educational attainment in adults.[9]

NAA may function as a neurotransmitter in the brain by acting on metabotropic glutamate receptors.[10]

See also

References

Further reading

External links

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