NCR1

Natural cytotoxicity triggering receptor 1 is a protein that in humans is encoded by the NCR1 gene.^[5][6] NCR1 has also been designated as CD335 (cluster of differentiation nomenclature), NKP46, NKp46, NK-p46, and LY94.^[7]

PDBOrtholog search: PDBe RCSB

AliasesNCR1, CD335, LY94, NK-p46, NKP46, natural cytotoxicity triggering receptor 1

External IDsOMIM: 604530; MGI: 1336212; HomoloGene: 3551; GeneCards: NCR1; OMA:NCR1 - orthologs

Chr.Chromosome 19 (human)^[1]

Quick facts Available structures, PDB ...

NCR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OLL, 1P6F
Identifiers
Aliases	NCR1, CD335, LY94, NK-p46, NKP46, natural cytotoxicity triggering receptor 1
External IDs	OMIM: 604530; MGI: 1336212; HomoloGene: 3551; GeneCards: NCR1; OMA:NCR1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 54,906,148 bp[1] End 54,916,140 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A1 Start 4,340,723 bp[2] End 4,348,163 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood spleen bone marrow cell gonad monocyte placenta liver right lobe of liver lymph node Top expressed in blood morula spleen granulocyte gastrula right lung lobe submandibular gland extensor digitorum longus muscle uterus upper arm More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane SWI/SNF complex membrane Biological process cellular defense response natural killer cell activation signal transduction regulation of immune response regulation of natural killer cell mediated cytotoxicity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9437 17086 Ensembl ENSG00000273535 ENSG00000277629 ENSG00000273916 ENSG00000275156 ENSG00000277824 ENSG00000277334 ENSG00000278362 ENSG00000275637 ENSG00000274053 ENSG00000275521 ENSG00000275822 ENSG00000277442 ENSG00000189430 ENSG00000284113 ENSG00000273506 ENSG00000276450 ENSG00000278025 ENSG00000288651 ENSMUSG00000062524 UniProt O76036 Q8C567 RefSeq (mRNA) NM_001145457 NM_001145458 NM_001242356 NM_001242357 NM_004829 NM_010746 NM_001368364 RefSeq (protein) NP_001138929 NP_001138930 NP_001229285 NP_001229286 NP_004820 NP_034876 NP_001355293 Location (UCSC) Chr 19: 54.91 – 54.92 Mb Chr 7: 4.34 – 4.35 Mb PubMed search [3] [4]
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