NDST1

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 is an enzyme. In humans, it is encoded by the NDST1 gene.^[5][6][7]

AliasesNDST1, HSST, NST1, MRT46, N-deacetylase/N-sulfotransferase 1, N-deacetylase and N-sulfotransferase 1

External IDsOMIM: 600853; MGI: 104719; GeneCards: NDST1

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 5 (human)^[1]

Quick facts Identifiers, Aliases ...

NDST1
Identifiers
Aliases	NDST1, HSST, NST1, MRT46, N-deacetylase/N-sulfotransferase 1, N-deacetylase and N-sulfotransferase 1
External IDs	OMIM: 600853; MGI: 104719; GeneCards: NDST1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1NST
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.8.2.8 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.1 Start 150,485,818 bp[1] End 150,558,211 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 E1 Start 60,817,566 bp[2] End 60,881,722 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium C1 segment olfactory bulb subthalamic nucleus inferior ganglion of vagus nerve right lobe of liver lateral nuclear group of thalamus mucosa of esophagus inferior olivary nucleus upper lobe of left lung Top expressed in right lung lobe left lung left lung lobe lacrimal gland epithelium of stomach left lobe of liver human fetus salivary gland vas deferens digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity sulfotransferase activity deacetylase activity catalytic activity hydrolase activity N-acetylglucosamine deacetylase activity protein binding [heparan sulfate-glucosamine N-sulfotransferase activity] heparan sulfate N-acetylglucosaminyltransferase activity heparan sulfate sulfotransferase activity Cellular component integral component of membrane Golgi apparatus membrane Golgi membrane Biological process cardiac septum development heparin biosynthetic process embryonic neurocranium morphogenesis coronary vasculature development respiratory gaseous exchange by respiratory system fibroblast growth factor receptor signaling pathway aorta development development of the heart glycosaminoglycan biosynthetic process animal organ morphogenesis embryonic viscerocranium morphogenesis polysaccharide biosynthetic process forebrain development metabolism protein sulfation inflammatory response midbrain development glycosaminoglycan metabolic process heparan sulfate proteoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process positive regulation of MAPK cascade positive regulation of smoothened signaling pathway sulfur compound metabolic process Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 3340 15531 Ensembl ENSG00000070614 ENSMUSG00000054008 UniProt P52848 Q3UHN9 RefSeq (mRNA) NM_001301063 NM_001543 NM_008306 NM_001348100 NM_001348101 NM_001348102 NM_001348103 NM_001348146 RefSeq (protein) NP_001287992 NP_001534 NP_032332 NP_001335029 NP_001335030 NP_001335031 NP_001335032 NP_001335075 Location (UCSC) Chr 5: 150.49 – 150.56 Mb Chr 18: 60.82 – 60.88 Mb PubMed search [3] [4]
Wikidata
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