NFKBIZ

NF-kappa-B inhibitor zeta (IκBζ) is a protein that in humans is encoded by the NFKBIZ gene.^[5][6][7] This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-κB proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene.^[8]

AliasesNFKBIZ, IKBZ, INAP, MAIL, NFKB inhibitor zeta

External IDsOMIM: 608004; MGI: 1931595; HomoloGene: 12734; GeneCards: NFKBIZ; OMA:NFKBIZ - orthologs

Chr.Chromosome 3 (human)^[1]

End101,861,022 bp^[1]

Quick facts Identifiers, Aliases ...

NFKBIZ
Identifiers
Aliases	NFKBIZ, IKBZ, INAP, MAIL, NFKB inhibitor zeta
External IDs	OMIM: 608004; MGI: 1931595; HomoloGene: 12734; GeneCards: NFKBIZ; OMA:NFKBIZ - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q12.3 Start 101,827,991 bp[1] End 101,861,022 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C1.1 Start 55,631,738 bp[2] End 55,659,262 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic epithelial cell pancreatic ductal cell palpebral conjunctiva skin of thigh parietal pleura trachea visceral pleura bone marrow cell gastric mucosa nasal epithelium Top expressed in granulocyte Paneth cell islet of Langerhans conjunctival fornix mucous cell of stomach stroma of bone marrow left lung lobe jejunum duodenum primary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding transcription coregulator activity Cellular component nucleus nuclear speck cytoplasmic ribonucleoprotein granule Biological process regulation of transcription by RNA polymerase II inflammatory response regulation of transcription, DNA-templated transcription, DNA-templated T cell receptor signaling pathway positive regulation of T-helper 17 cell differentiation positive regulation of inflammatory response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64332 80859 Ensembl ENSG00000144802 ENSMUSG00000035356 UniProt Q9BYH8 Q9EST8 RefSeq (mRNA) NM_031419 NM_001005474 NM_001159394 NM_001159395 NM_030612 RefSeq (protein) NP_001005474 NP_113607 NP_001152866 NP_001152867 NP_085115 Location (UCSC) Chr 3: 101.83 – 101.86 Mb Chr 16: 55.63 – 55.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close