Sodium-hydrogen antiporter 3 regulator 1

SLC9A3R1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1G9O, 1GQ4, 1GQ5, 1I92, 2D10, 2JXO, 2KJD, 2KRG, 2M0T, 2M0U, 2M0V, 2OZF, 4JL7, 4LMM, 4MPA, 4N6X, 4PQW, 4Q3H
Identifiers
Aliases	SLC9A3R1, EBP50, NHERF, NHERF-1, NHERF1, NPHLOP2, Sodium-hydrogen antiporter 3 regulator 1, SLC9A3 regulator 1
External IDs	OMIM: 604990; MGI: 1349482; HomoloGene: 3137; GeneCards: SLC9A3R1; OMA:SLC9A3R1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	74,769,353 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	115,072,007 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; olfactory zone of nasal mucosa; ; mucosa of transverse colon; ; right adrenal gland; ; mucosa of ileum; ; right adrenal cortex; ; right lobe of liver; ; jejunal mucosa; ; left adrenal cortex; ; minor salivary glands;
	Top expressed in
	jejunum; ; retinal pigment epithelium; ; yolk sac; ; ileum; ; duodenum; ; left lobe of liver; ; granulocyte; ; right kidney; ; left colon; ; primitive streak;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein self-association; growth factor receptor binding; dopamine receptor binding; beta-catenin binding; beta-2 adrenergic receptor binding; phosphatase binding; signaling receptor binding; molecular adaptor activity; protein binding; protein-containing complex binding; protein domain specific binding; chloride channel regulator activity; PDZ domain binding; myosin II binding; protein N-terminus binding;
Cellular component	brush border membrane; vesicle; endomembrane system; nucleus; cell periphery; cell projection; actin cytoskeleton; perinuclear region of cytoplasm; apical part of cell; ruffle; stereocilium; extracellular exosome; membrane; membrane raft; microvillus membrane; cytoplasm; microvillus; stereocilium tip; apical plasma membrane; sperm midpiece; filopodium; plasma membrane; intracellular membrane-bounded organelle;
Biological process	negative regulation of cell population proliferation; regulation of protein kinase activity; positive regulation of intrinsic apoptotic signaling pathway; regulation of cell size; actin cytoskeleton organization; renal absorption; regulation of sodium:proton antiporter activity; phospholipase C-activating dopamine receptor signaling pathway; microvillus assembly; bile acid secretion; cAMP-mediated signaling; establishment of Golgi localization; hearing; renal phosphate ion absorption; gland morphogenesis; negative regulation of cell motility; negative regulation of protein kinase B signaling; auditory receptor cell stereocilium organization; negative regulation of phosphatidylinositol 3-kinase signaling; establishment of epithelial cell apical/basal polarity; negative regulation of ERK1 and ERK2 cascade; adenylate cyclase-activating dopamine receptor signaling pathway; regulation of excretion; cellular phosphate ion homeostasis; negative regulation of mitotic cell cycle; glutathione transport; renal sodium ion transport; negative regulation of sodium:proton antiporter activity; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of cell migration; regulation of cell shape; Wnt signaling pathway; negative regulation of sodium ion transport; nuclear migration; protein localization to plasma membrane; positive regulation of ion transmembrane transport; protein-containing complex assembly; negative regulation of canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	9368
	26941
	ENSG00000109062
	ENSMUSG00000020733
	O14745
	P70441
	NM_004252
	NM_012030
	NP_004243
	NP_036160
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium-hydrogen antiporter 3 regulator 1 (SLC9A3R1) is a human protein. It is a regulator of Sodium-hydrogen antiporter 3 and is encoded by the gene SLC9A3R1. It is also known as ERM Binding Protein 50 (EBP50) or Na+/H+ Exchanger Regulatory Factor (NHERF1). It is believed to interact via long-range allostery, involving significant protein dynamics.