NITD008

NITD008
Clinical data
Trade names	NITD008
Identifiers
	IUPAC name (2R,3R,4R,5R)-2-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3-ethynyl-5-(hydroxymethyl)tetrahydrofuran-3,4-diol;
CAS Number	1044589-82-3 ;
PubChem CID	44633776;
ChemSpider	26376187;
UNII	LKI7T3WQ2E;
ChEMBL	ChEMBL1630221;
CompTox Dashboard (EPA)	DTXSID701159354 ;
Chemical and physical data
Formula	C13H14N4O4
Molar mass	290.279 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C#C[C@]1([C@@H]([C@H](O[C@H]1N2C=CC3=C2N=CN=C3N)CO)O)O;
	InChI InChI=1S/C13H14N4O4/c1-2-13(20)9(19)8(5-18)21-12(13)17-4-3-7-10(14)15-6-16-11(7)17/h1,3-4,6,8-9,12,18-20H,5H2,(H2,14,15,16)/t8-,9-,12-,13-/m1/s1; Key:NKRAIOQPSBRMOV-NRMKKVEVSA-N;

NITD008 is an antiviral drug classified as an adenosine analog (a type of nucleoside analog). It was developed as a potential treatment for flavivirus infections and shows broad spectrum antiviral activity against many related viruses such as dengue virus, West Nile virus, yellow fever virus, Powassan virus, hepatitis C virus, Kyasanur Forest disease virus, Omsk hemorrhagic fever virus, and Zika virus.^[1]^[2]^[3] However, NITD008 proved too toxic in pre-clinical animal testing to be suitable for human trials, but it continues to be used in research to find improved treatments for emerging viral diseases.^[4]

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