NJK14047

NJK14047
Identifiers
	IUPAC name N-cyclopropyl-3-[4-[4-(2,3-dihydroxypropoxy)benzoyl]phenyl]-4-methylbenzamide;
CAS Number	1800576-41-3;
PubChem CID	135395450;
ChemSpider	71060140;
Chemical and physical data
Formula	C27H27NO5
Molar mass	445.515 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=C(C=C(C=C1)C(=O)NC2CC2)C3=CC=C(C=C3)C(=O)C4=CC=C(C=C4)OCC(CO)O;
	InChI InChI=1S/C27H27NO5/c1-17-2-3-21(27(32)28-22-10-11-22)14-25(17)18-4-6-19(7-5-18)26(31)20-8-12-24(13-9-20)33-16-23(30)15-29/h2-9,12-14,22-23,29-30H,10-11,15-16H2,1H3,(H,28,32); Key:ZQIUCYZGBDPMLG-UHFFFAOYSA-N;

NJK14047 is a drug which acts as a selective inhibitor of the enzyme p38 mitogen-activated protein kinase (p38 MAPK). It has antiviral and antiinflammatory effects and was originally developed as a potential treatment for inflammatory lung conditions such as influenza. Subsequent research has also shown promise for various other conditions in which inflammation plays a role, including Alzheimer's disease, asthma, arthritis and psoriasis.^[1]^[2]^[3]^[4]

FormulaC₂₇H₂₇NO₅

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Identifiers

IUPAC name N-cyclopropyl-3-[4-[4-(2,3-dihydroxypropoxy)benzoyl]phenyl]-4-methylbenzamide
CAS Number	1800576-41-3
PubChem CID	135395450
ChemSpider	71060140
Chemical and physical data
Formula	C₂₇H₂₇NO₅
Molar mass	445.515 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC1=C(C=C(C=C1)C(=O)NC2CC2)C3=CC=C(C=C3)C(=O)C4=CC=C(C=C4)OCC(CO)O
InChI InChI=1S/C27H27NO5/c1-17-2-3-21(27(32)28-22-10-11-22)14-25(17)18-4-6-19(7-5-18)26(31)20-8-12-24(13-9-20)33-16-23(30)15-29/h2-9,12-14,22-23,29-30H,10-11,15-16H2,1H3,(H,28,32) Key:ZQIUCYZGBDPMLG-UHFFFAOYSA-N