NOP2 nucleolar protein, also called 28S rRNA (cytosine(4447)-C(5))-methyltransferase, is an enzyme that in humans is encoded by the NOP2 gene (previously NOL1).[5][6]
AliasesNOP2, NOL1, NOP120, NSUN1, p120, NOP2 nucleolar protein Quick facts Identifiers, Aliases ...
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The protein encoded by this gene is a nucleolar antigen expressed in proliferating cells. It is not detectable in non-proliferating normal tissue but is detectable in many human tumors.[7]
Overexpression of p120 leads to malignant transformation of 3T3 cells while treatment with antisense p120 mRNA causes the transformed cells to revert to their original non-malignant phenotype.[8] The p120 protein displays a dramatic increase in expression at the G1/S transition suggesting that p120 regulates the cell cycle and nucleolar activity that is required for cell proliferation.[9]
