NPR1

NPR1
Identifiers
Aliases	NPR1, ANPRA, ANPa, GUC2A, GUCY2A, NPRA, natriuretic peptide receptor 1
External IDs	OMIM: 108960; MGI: 97371; HomoloGene: 37367; GeneCards: NPR1; OMA:NPR1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	153,693,992 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	90,373,173 bp
RNA expression pattern
	Top expressed in
	Descending thoracic aorta; ; ascending aorta; ; right uterine tube; ; gastric mucosa; ; left uterine tube; ; right coronary artery; ; left coronary artery; ; subcutaneous adipose tissue; ; right lung; ; triceps brachii muscle;
	Top expressed in
	yolk sac; ; spermatocyte; ; muscle of thigh; ; blastocyst; ; morula; ; adrenal gland; ; lip; ; esophagus; ; thyroid gland; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein kinase activity; nucleotide binding; G protein-coupled peptide receptor activity; hormone binding; guanylate cyclase activity; GTP binding; lyase activity; natriuretic peptide receptor activity; phosphorus-oxygen lyase activity; ATP binding; peptide hormone binding; adenylate cyclase activity; protein kinase binding; peptide receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; receptor complex; guanylate cyclase complex, soluble; intracellular anatomical structure;
Biological process	negative regulation of smooth muscle cell proliferation; regulation of cardiac conduction; intracellular signal transduction; positive regulation of renal sodium excretion; positive regulation of urine volume; body fluid secretion; cyclic nucleotide biosynthetic process; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; cGMP biosynthetic process; protein phosphorylation; cell surface receptor signaling pathway; regulation of vascular permeability; dopamine metabolic process; negative regulation of cell growth; negative regulation of angiogenesis; G protein-coupled receptor signaling pathway; blood vessel diameter maintenance; positive regulation of cGMP-mediated signaling; cGMP-mediated signaling; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	4881
	18160
	ENSG00000169418
	ENSMUSG00000027931
	P16066
	P18293
	NM_000906
	NM_008727
	NP_000897
	NP_032753
	Wikidata
View/Edit Human	View/Edit Mouse

Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR1 gene.

AliasesNPR1, ANPRA, ANPa, GUC2A, GUCY2A, NPRA, natriuretic peptide receptor 1

External IDsOMIM: 108960; MGI: 97371; HomoloGene: 37367; GeneCards: NPR1; OMA:NPR1 - orthologs

Chr.Chromosome 1 (human)^[1]

End153,693,992 bp^[1]

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