NPRL2

NPRL2
Identifiers
Aliases	NPRL2, NPR2, NPR2L, TUSC4, NPR2-like, GATOR1 complex subunit, FFEVF2, NPR2 like, GATOR1 complex subunit
External IDs	OMIM: 607072; MGI: 1914482; GeneCards: NPRL2
Gene location (Human)
Chr.	Chromosome 3 (human)
End	50,350,826 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	107,422,905 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; right hemisphere of cerebellum; ; body of pancreas; ; Skeletal muscle tissue of rectus abdominis; ; muscle of thigh; ; pituitary gland; ; anterior pituitary; ; prefrontal cortex; ; right frontal lobe; ; apex of heart;
	Top expressed in
	interventricular septum; ; primary oocyte; ; right kidney; ; proximal tubule; ; spermatocyte; ; neural tube; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; secondary oocyte; ; nucleus of stria terminalis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein kinase activity; protein binding; GTPase activator activity;
Cellular component	GATOR1 complex; lysosome; lysosomal membrane; membrane;
Biological process	negative regulation of TOR signaling; cellular response to amino acid starvation; negative regulation of kinase activity; positive regulation of GTPase activity; protein phosphorylation; cellular response to nitrogen starvation; positive regulation of autophagy; regulation of autophagosome assembly;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10641
	56032
	ENSG00000114388
	ENSMUSG00000010057
	Q8WTW4
	Q9WUE4
	NM_006545
	NM_018879
	NP_006536
	NP_061367
	Wikidata
View/Edit Human	View/Edit Mouse

Nitrogen permease regulator 2-like protein (NPRL2) also known as tumor suppressor candidate 4 (TUSC4) is a protein that in humans is encoded by the NPRL2 gene.^[5]^[6]