NRON
From Wikipedia, the free encyclopedia
| ncRNA Repressor of NFAT (nuclear factor of activated T cells) | |
|---|---|
 Predicted secondary structure and sequence conservation of NRON | |
| Identifiers | |
| Symbol | NRON |
| Rfam | RF00636 |
| Other data | |
| RNA type | Gene |
| Domain | Eukaryota |
| SO | SO:0001263 |
| PDB structures | PDBe |
NRON also known as ncRNA repressor of the nuclear factor of activated T cells is a non-coding RNA involved in repressing NFAT.[1] The function of this ncRNA was identified by a large-scale screen of 512 non-coding RNAs discovered in earlier EST sequencing projects.[2][3]
Each of the RNAs that were conserved between human and mouse were knocked down using shRNAs. The resulting cell-lines were screened for changes in activity of NFAT.
