NUAK2

NUAK2
Identifiers
Aliases	NUAK2, SNARK, NUAK family kinase 2, ANPH2
External IDs	OMIM: 608131; MGI: 1921387; GeneCards: NUAK2
Enzyme activity
Gene location (Human)
Chr.	Chromosome 1 (human)
End	205,321,745 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	132,261,226 bp
RNA expression pattern
	Top expressed in
	blood; ; mucosa of ileum; ; gingival epithelium; ; mucosa of pharynx; ; granulocyte; ; epithelium of esophagus; ; palpebral conjunctiva; ; renal medulla; ; mucosa of transverse colon; ; kidney tubule;
	Top expressed in
	right kidney; ; jejunum; ; granulocyte; ; proximal tubule; ; human kidney; ; mesenteric lymph nodes; ; ileum; ; epithelium of lens; ; colon; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein binding; protein kinase activity; metal ion binding; kinase activity; transferase activity; protein serine/threonine kinase activity; ATP binding; magnesium ion binding;
Cellular component	cytoplasm; nucleus;
Biological process	phosphorylation; apoptotic process; actin cytoskeleton organization; negative regulation of apoptotic process; intracellular signal transduction; protein phosphorylation; cellular response to glucose starvation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	81788
	74137
	ENSG00000163545
	ENSMUSG00000009772
	Q9H093
	Q8BZN4
	NM_030952
	NM_001195025; NM_028778
	NP_112214
	NP_001181954; NP_083054
	Wikidata
View/Edit Human	View/Edit Mouse

NUAK family SNF1-like kinase 2 also known as SNF1/AMP kinase-related kinase (SNARK) is an enzyme that in humans is encoded by the NUAK2 gene.^[5]^[6] Its deficiency in humans causes anencephaly, a severe form of anterior neural tube defect that curtails brain development.^[7]