NV-5440

NV-5440
Identifiers
	IUPAC name 2-[4-[5-[[4-(2-cyanophenyl)piperazin-1-yl]methyl]-2,4-dimethylbenzoyl]piperazin-1-yl]benzenesulfonamide;
CAS Number	2226614-88-4;
PubChem CID	134500648;
ChemSpider	98644474;
CompTox Dashboard (EPA)	DTXSID201336668 ;
Chemical and physical data
Formula	C31H36N6O3S
Molar mass	572.73 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=CC(=C(C=C1CN2CCN(CC2)C3=CC=CC=C3C#N)C(=O)N4CCN(CC4)C5=CC=CC=C5S(=O)(=O)N)C;
	InChI InChI=1S/C31H36N6O3S/c1-23-19-24(2)27(20-26(23)22-34-11-13-35(14-12-34)28-8-4-3-7-25(28)21-32)31(38)37-17-15-36(16-18-37)29-9-5-6-10-30(29)41(33,39)40/h3-10,19-20H,11-18,22H2,1-2H3,(H2,33,39,40); Key:BREWSTIKWAQLCH-UHFFFAOYSA-N;

NV-5440 is a drug which acts as both a non-specific inhibitor of the glucose transporters and also a selective inhibitor of mTORC1, with no significant action at the related mTORC2 subtype. Compounds of this type have potential application in the treatment of cancer, and it is also used for research into the links between calorie restriction and longevity.^[1]^[2]^[3]

CAS Number

2226614-88-4

PubChem CID

134500648

ChemSpider

98644474

CompTox Dashboard (EPA)

DTXSID201336668

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NV-5440

References

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Identifiers

IUPAC name 2-[4-[5-[[4-(2-cyanophenyl)piperazin-1-yl]methyl]-2,4-dimethylbenzoyl]piperazin-1-yl]benzenesulfonamide
CAS Number	2226614-88-4
PubChem CID	134500648
ChemSpider	98644474
CompTox Dashboard (EPA)	DTXSID201336668
Chemical and physical data
Formula	C₃₁H₃₆N₆O₃S
Molar mass	572.73 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC1=CC(=C(C=C1CN2CCN(CC2)C3=CC=CC=C3C#N)C(=O)N4CCN(CC4)C5=CC=CC=C5S(=O)(=O)N)C
InChI InChI=1S/C31H36N6O3S/c1-23-19-24(2)27(20-26(23)22-34-11-13-35(14-12-34)28-8-4-3-7-25(28)21-32)31(38)37-17-15-36(16-18-37)29-9-5-6-10-30(29)41(33,39)40/h3-10,19-20H,11-18,22H2,1-2H3,(H2,33,39,40) Key:BREWSTIKWAQLCH-UHFFFAOYSA-N