Napabucasin

Drug classSTAT3 inhibitor

CAS Number

• 83280-65-3

PubChem CID

• 10331844

FormulaC₁₄H₈O₄

Napabucasin

Clinical data
Drug class	STAT3 inhibitor
Identifiers
IUPAC name 2-acetylbenzo[f][1]benzofuran-4,9-dione
CAS Number	83280-65-3
PubChem CID	10331844
Chemical and physical data
Formula	C14H8O4
Molar mass	240.214 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(=O)C1=CC2=C(O1)C(=O)C3=CC=CC=C3C2=O
InChI InChI=1S/C14H8O4/c1-7(15)11-6-10-12(16)8-4-2-3-5-9(8)13(17)14(10)18-11/h2-6H,1H3 Key:DPHUWDIXHNQOSY-UHFFFAOYSA-N

Napabucasin (BBI-608) is a natural product found in the inner bark of the tree Handroanthus impetiginosus, that acts as an inhibitor of the transcription factor protein STAT3. It has potential applications in the treatment of cancer, acting as a stemness inhibitor.^{[1][2][3][4][5]}