Nardosinone

Nardosinone
Names
	Preferred IUPAC name (3aR,9R,9aR,9bS)-1,1,9,9a-Tetramethyl-1,3a,4,7,8,9,9a,9b-octahydro-5H-naphtho[2,1-c][1,2]dioxol-5-one
Identifiers
CAS Number	23720-80-1 ;
3D model (JSmol)	Interactive image;
ChemSpider	147074;
PubChem CID	168136;
CompTox Dashboard (EPA)	DTXSID50946520 ;
	InChI InChI=1S/C15H22O3/c1-9-6-5-7-10-11(16)8-12-13(15(9,10)4)14(2,3)18-17-12/h7,9,12-13H,5-6,8H2,1-4H3/t9-,12-,13+,15+/m1/s1 Key: KXGHHSIMRWPVQM-JWFUOXDNSA-N; InChI=1/C15H22O3/c1-9-6-5-7-10-11(16)8-12-13(15(9,10)4)14(2,3)18-17-12/h7,9,12-13H,5-6,8H2,1-4H3/t9-,12-,13+,15+/m1/s1 Key: KXGHHSIMRWPVQM-JWFUOXDNBH;
	SMILES O=C2/C1=C/CC[C@@H](C)[C@@]1([C@@H]3C(OO[C@@H]3C2)(C)C)C;
Properties
Chemical formula	C15H22O3
Molar mass	250.338 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Nardosinone is a sesquiterpene and chemical constituent of Nardostachys jatamansi.^[1] In in vitro studies, the compound has demonstrated concentration-dependent enhancement of bucladesine and staurosporine-induced neurite outgrowth.^[2] Nardosinone has similarly been demonstrated to enhance NGF-mediated neurite outgrowth and synaptogenesis from PC12D cells.^[3]

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Additionally, nardosinone has demonstrated cytotoxic activity against cultured P-388 lymphocytic leukemia cells.^[4]

References