Nargenicin

Nargenicin
Clinical data
ATC code	none;
Pharmacokinetic data
Excretion	~
Identifiers
CAS Number	70695-02-2 ;
PubChem CID	6436286;
ChemSpider	4885360 ;
UNII	XP2QP458K4;
Chemical and physical data
Formula	C28H37NO8
Molar mass	515.603 g·mol−1
	SMILES O=C2O[C@H]([C@H](O)C)[C@@H](\C=C(/C)[C@]51O[C@H]4[C@H](\C=C/[C@@H]1C[C@@H]2OC)[C@H]5[C@H](O)[C@H]([C@H]4OC(=O)c3ccc[nH]3)C)C;
	InChI InChI=1S/C28H37NO8/c1-13-11-14(2)28-17(12-20(34-5)27(33)35-23(13)16(4)30)8-9-18-21(28)22(31)15(3)24(25(18)37-28)36-26(32)19-7-6-10-29-19/h6-11,13,15-18,20-25,29-31H,12H2,1-5H3/b14-11+/t13-,15-,16-,17-,18-,20+,21+,22-,23+,24-,25+,28-/m1/s1 ; Key:YEUSSARNQQYBKH-KFIBIINQSA-N ;
	(verify)

Nargenicin (CP-47,444, CS-682) is a 28 carbon macrolide with a fused tricyclic core that has in addition a unique ether bridge. The polyketide antibiotic was isolated from Nocardia argentinensis.^[1] Nargenicin is effective towards gram-positive bacteria and been shown to have strong antibacterial activity against Staphylococcus aureus, including strains that are resistant to methicillin.^[2] It has also been shown to induce cell differentiation and inhibit cell proliferation in a human myeloid leukemia cell line.^[3]

References