Neamine
Chemical compound
From Wikipedia, the free encyclopedia
Neamine (neomycin A) is a degradation product of the aminoglycoside antibiotic neomycin.[1] Several derivatives of neamine are active against susceptible and resistant Gram-positive and Gram-negative bacteria.[2]
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| Other names | Neomycin A |
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| Formula | C12H26N4O6 |
| Molar mass | 322.362 g·mol−1 |
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Biosynthesis
Neamine is a biosynthetic intermediate in the pathway which bacteria such as Streptomyces kanamyceticus use to make aminoglycoside antibiotics including lividomycin, neomycin and kanamycin. The immediate precursor is the aldehyde, 6'-oxoparomamine, which is acted on by the enzyme neamine transaminase:[3][4][5]
