Necitumumab
Recombinant human monoclonal antibody
From Wikipedia, the free encyclopedia
Necitumumab (INN) is a recombinant human IgG1 monoclonal antibody used as an antineoplastic, which is manufactured by Eli Lilly. It binds to the epidermal growth factor receptor (EGFR).[3] The US FDA approved necitumumab under the brand name Portrazza for use with gemcitabine and cisplatin in previously untreated metastatic squamous non-small-cell lung carcinoma (NSCLC).[4][5][2] It was counterproductive in non-squamous non-small-cell lung carcinoma.[2][6]
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| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Human |
| Target | EGFR |
| Clinical data | |
| Trade names | Portrazza |
| AHFS/Drugs.com | Multum Consumer Information |
| License data |
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| Routes of administration | Intravenous infusion |
| ATC code | |
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| Legal status | |
| Pharmacokinetic data | |
| Elimination half-life | ~14 days |
| Identifiers | |
| CAS Number | |
| DrugBank | |
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| UNII | |
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| Chemical and physical data | |
| Formula | C6436H9958N1702O2020S42 |
| Molar mass | 144844.87 g·mol−1 |
  (what is this?) (verify) | |
