Nef synthesis
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| Nef synthesis | |
|---|---|
| Named after | John Ulric Nef |
| Reaction type | Coupling reaction |
| Identifiers | |
| RSC ontology ID | RXNO:0000506 |
In organic chemistry, Nef synthesis is the addition of sodium acetylides to aldehydes and ketones to yield propargyl alcohols.[1][2][3][4][5][6] It is named for John Ulric Nef, who discovered the reaction in 1899.
This process is often erroneously referred to as the Nef reaction,[4][7][8][9] which is an unrelated chemical transformation discovered by the same chemist.
