Neferseshemre's early career started off in the royal palace. He was overseer of the kings repast, overseer of the two chambers of the king, overseer of the two cool rooms of the palace, overseer of the residence and superintendent of priests and guards of Teti's pyramid. As vizier, Neferseshemre also held the positions of overseer of the scribes of the king's documents, overseer of all the works of the king, and overseer of the six great courts.
Neferseshemre and his wife Semdet had several children and one of them was named Hekaib. At least two of the sons of the vizier had their images and names erased from Neferseshemre's tomb. [1]