Neil Brockdorff

Brockdorff was educated at Hampstead School, the University of Sussex (BSc)^[1] and the University of Glasgow (PhD).^[2]

X inactivation is an important model for understanding how epigenetic mechanisms, for example modification of DNA and histone proteins around which DNA is packaged, contribute to gene regulation in developmental biology.^[7][8] In earlier work Brockdorff demonstrated that an unusual functional RNA molecule, XIST, controls the X inactivation process.^[9][10] Building on this finding he has elucidated key steps in XIST gene regulation during early development, and has defined major pathways through which XIST RNA induces chromosome wide gene silencing.^{[7][11][12][13]}

Brockdorff is a member of the European Molecular Biology Organization (EMBO), a Fellow of the Royal Society (FRS), a Fellow of the Academy of Medical Sciences (FMedSci) and a Fellow of the Royal Society of Biology (FRSB).^{[citation needed]}

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