Neopentalenolactone D synthase
Class of enzymes
From Wikipedia, the free encyclopedia
Neopentalenolactone D synthase (EC 1.14.13.171, ptlE (gene)) is an enzyme with systematic name 1-deoxy-11-oxopentalenate,NADH:oxygen oxidoreductase (neopentalenolactone-D forming).[1] This enzyme catalyses the following chemical reaction
| Neopentalenolactone D synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.171 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The four substrates of this enzyme are 1-deoxy-11-oxopentalenic acid, reduced nicotinamide adenine dinucleotide phosphate (NADPH), oxygen, and a proton. It products are neopentalenolactone D, oxidised NADP+, and water.[2] The starting ketone is made as part of a biosynthetic pathway in Streptomyces avermitilis which leads to pentalenolactone and related compounds.[1][3]
The enzyme is a Baeyer-Villiger monooxygenase that uses flavin adenine dinucleotide as a cofactor.[1]
See also
- Pentalenolactone D synthase which uses the same starting material but inserts oxygen to form an alternative lactone.
