Neopterin
From Wikipedia, the free encyclopedia
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| Names | |
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| Preferred IUPAC name
2-Amino-6-(1,2,3-trihydroxypropyl)pteridin-4(1H)-one | |
| Identifiers | |
3D model (JSmol) |
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| ChemSpider | |
| DrugBank | |
| ECHA InfoCard | 100.016.296 |
| MeSH | Neopterin |
PubChem CID |
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| UNII | |
CompTox Dashboard (EPA) |
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| Properties | |
| C9H11N5O4 | |
| Molar mass | 253.215 g/mol |
| Density | 2.02 g/cm3 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Neopterin is an organic compound belonging to the pteridine class of heterocyclic compounds.
Neopterin belongs to the chemical group known as pteridines. It is synthesised by human macrophages upon stimulation with the cytokine interferon-gamma and is indicative of a pro-inflammatory immune status. Neopterin serves as a marker of cellular immune system activation.[1] In humans neopterin follows a circadian (daily) and circaseptan (weekly) rhythm.[2]
The biosynthesis of neopterin occurs in two steps from guanosine triphosphate (GTP). The first being catalyzed by GTP cyclohydrolase, which opens the ribose group. Phosphatases next catalyze the hydrolysis of the phosphate ester group.[3]
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