In 2017, Duron spent the season with the Low-A Lowell Spinners, pitching to a 3-5 record and 3.35 ERA with 36 strikeouts in 53.2 innings of work across 13 appearances (12 starts). The next year, he split the season between the rookie-level GCL Red Sox and the Single-A Greenville Drive, posting a cumulative 0-6 record and 7.53 ERA with 24 strikeouts in 28.2 innings pitched in 10 games (6 starts). On March 28, 2019, Duron was released by the Red Sox organization.[4]
Southern Illinois Miners
On April 29, 2019, Duron signed with the Southern Illinois Miners of the Frontier League.[5] In 10 games, he recorded a 2-0 record and 1.35 ERA with 18 strikeouts and 2 saves in 13.1 innings pitched.
Seattle Mariners
On June 7, 2019, Duron signed a minor league contract with the Seattle Mariners organization.[6] He finished the year appearing in 25 games for the High-A Modesto Nuts, logging a 3-1 record and 2.23 ERA with 51 strikeouts in 36+1⁄3 innings pitched.
Duron did not play in a game in 2020 due to the cancellation of the minor league season because of the COVID-19 pandemic.[7] He split 2021 between the Double-A Arkansas Travelers and the Triple-A Tacoma Rainiers.[2] He was a combined 4–2 with four saves and a 4.50 ERA in 38 relief appearances covering 42 innings in which he struck out 43 batters.[2] He became a free agent following the season on November 7, 2021.[8]
Philadelphia Phillies
On January 9, 2022, Duron signed a minor league contract with the Philadelphia Phillies organization.[9] In 2022, pitching for the Triple-A Lehigh Valley IronPigs, Duron worked to a 4–7 record with seven saves and a 2.77 ERA in 52 relief appearances covering 48.2 innings in which he struck out 63 batters (11.7 strikeouts/9 innings), and induced a 50.4% ground-ball percentage.[2][10] He was named a 2022 MiLB Organization All Star.[11]
On July 12, 2022, Duron was selected to the 40-man roster and promoted to the major leagues for the first time.[12] He made his major league debut on July 13. His fastball averaged 97.2mph during his MLB appearance.[10] He elected free agency on November 10.[13]
San Francisco Giants
On December 15, 2022, Duron signed a minor league contract with the San Francisco Giants organization.[14] He began the 2023 season with the Triple-A Sacramento River Cats, where he posted a 1-1 record and 2.25 ERA with 9 strikeouts in 8.0 innings pitched across 6 appearances.
San Diego Padres
On April 21, 2023, Duron was traded to the San Diego Padres in exchange for cash considerations.[15] Despite strong results in Sacramento, Duron struggled to a 12.91 ERA with 8 strikeouts in 7+2⁄3 innings across 8 games for the Triple–A El Paso Chihuahuas. He was released by the Padres organization on June 9.[16]
Lancaster Barnstormers
On July 18, 2023, Duron signed with the Lancaster Barnstormers of the Atlantic League of Professional Baseball.[17] In 23 games for the Barnstormers, he posted a 2.01 ERA with 36 strikeouts and 2 saves in 22+1⁄3 innings pitched. With Lancaster, Duron won the Atlantic League championship.[18] He became a free agent following the 2023 season.