Since 1988 Manzone-Saquet is a president of the Union of Monegasque Women (Union des Femmes Monégasques).[1] She is a women's rights activist; however, she doesn't consider herself a feminist.[2] Manzone-Saquet notes that such developments as the termination of pregnancy for medical reasons, divorce by mutual consent, parental leave and part-time work were achieved thank to the involvement of women in the National Council.[3]
From 2008 until 2013 Manzone-Saquet was a member of the National Council of Monaco from Union Monegasque (Union Des Monégasques).[4] She was the oldest female member of the National Council.[5] Manzone-Saquet chaired the Commission on Women's and Family Rights.[6] In 2011–2013, Manzone-Saquet was a Representative of Monaco in the Parliamentary Assembly of the Council of Europe.[7]