Nicotinate-nucleotide diphosphorylase (carboxylating)
Class of enzymes
From Wikipedia, the free encyclopedia
Nicotinate-nucleotide diphosphorylase (carboxylating) (EC 2.4.2.19) is an enzyme that catalyzes the chemical reaction
| Nicotinate-nucleotide diphosphorylase (carboxylating) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Nicotinate-nucleotide pyrophosphorylase (carboxylating) hexamer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 2.4.2.19 | ||||||||
| CAS no. | 37277-74-0 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme is named for the reaction in the direction from the nucleotide to quinolinic acid but in the mammalian liver only proceeds in the direction shown, with carbon dioxide and pyrophosphate (PPi) as byproducts.[1][2] This reaction is part of the biosythesis pathway to the coenzyme, nicotinamide adenine dinucleotide, in both plants and animals.[3]
This enzyme is a glycosyltransferase, specifically a pentosyltransferase. The systematic name of this enzyme class is nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating). Other names in common use include quinolinate phosphoribosyltransferase (decarboxylating), quinolinic acid phosphoribosyltransferase, QAPRTase, NAD+ pyrophosphorylase, nicotinate mononucleotide pyrophosphorylase (carboxylating), and quinolinic phosphoribosyltransferase.[4]
