+ electron
acceptor
Nicotine dehydrogenase
Enzyme
From Wikipedia, the free encyclopedia
Nicotine dehydrogenase (EC 1.5.99.4) is an enzyme that catalyzes the chemical reaction
-6-hydroxynicotine.svg)
| Nicotine dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.5.99.4 | ||||||||
| CAS no. | 37256-31-8 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The three substrates of this enzyme are nicotine, water and an electron acceptor. Its products are 6-hydroxynicotine and the corresponding reduced acceptor.[1][2][3][4]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with other acceptors. The systematic name of this enzyme class is nicotine:acceptor 6-oxidoreductase (hydroxylating). Other names in common use include nicotine oxidase, D-nicotine oxidase, nicotine:(acceptor) 6-oxidoreductase (hydroxylating), and L-nicotine oxidase. It is a metalloprotein that contains flavin mononucleotide.[1]
