Nitrosourea
Chemical compound
From Wikipedia, the free encyclopedia
Nitrosourea is both the name of a molecule, and a class of compounds that include a nitroso (R-NO) group and a urea.
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| Names | |||
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| IUPAC name
Nitrosourea | |||
| Identifiers | |||
3D model (JSmol) |
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PubChem CID |
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CompTox Dashboard (EPA) |
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| Properties | |||
| CH3N3O2 | |||
| Molar mass | 89.054 g·mol−1 | ||
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Examples
Examples include:
- Arabinopyranosyl-N-methyl-N-nitrosourea (Aranose)
- Carmustine (BCNU, BiCNU)
- Chlorozotocin
- Ethylnitrosourea (ENU)
- Fotemustine
- Lomustine (CCNU)
- Nimustine
- N-Nitroso-N-methylurea (NMU)
- Ranimustine (MCNU)
- Semustine
- Streptozocin (Streptozotocin)
Nitrosourea compounds are DNA alkylating agents and are often used in chemotherapy.[1] They are lipophilic and thus can cross the blood–brain barrier, making them useful in the treatment of brain tumors such as glioblastoma multiforme.[2]
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Side effects
Some nitrosoureas (e.g. lomustine) have been associated with the development of interstitial lung disease.[3]
