ONECUT1
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
One cut homeobox 1 is a protein that in humans is encoded by the ONECUT1 gene. [5]
Function
This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. It is important for the differentiation of pancreas endocrine cells,[6] and mutations in ONECUT1 are involved in juvenile diabetes.[7] Alternative splicing results in multiple transcript variants.
