OPCML

Opioid-binding protein/cell adhesion molecule is a protein that in humans is encoded by the OPCML gene.^[5][6]

AliasesOPCML, IGLON1, OBCAM, OPCM, opioid binding protein/cell adhesion molecule-like, opioid binding protein/cell adhesion molecule like

External IDsOMIM: 600632; MGI: 97397; HomoloGene: 55663; GeneCards: OPCML; OMA:OPCML - orthologs

Chr.Chromosome 11 (human)^[1]

End133,532,501 bp^[1]

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OPCML
Identifiers
Aliases	OPCML, IGLON1, OBCAM, OPCM, opioid binding protein/cell adhesion molecule-like, opioid binding protein/cell adhesion molecule like
External IDs	OMIM: 600632; MGI: 97397; HomoloGene: 55663; GeneCards: OPCML; OMA:OPCML - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q25 Start 132,414,977 bp[1] End 133,532,501 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A4|9 13.73 cM Start 27,790,775 bp[2] End 28,925,410 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 middle temporal gyrus endothelial cell retinal pigment epithelium orbitofrontal cortex postcentral gyrus superior frontal gyrus Brodmann area 46 entorhinal cortex Region I of hippocampus proper Top expressed in primary motor cortex lateral septal nucleus ventromedial nucleus cingulate gyrus subiculum piriform cortex lateral geniculate nucleus anterior amygdaloid area prefrontal cortex lateral hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component anchored component of membrane plasma membrane membrane extracellular region Biological process neuron recognition cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4978 330908 Ensembl ENSG00000183715 ENSMUSG00000062257 UniProt Q14982 n/a RefSeq (mRNA) NM_001012393 NM_002545 NM_001319103 NM_001319104 NM_001319105 NM_001319106 NM_177906 RefSeq (protein) NP_001012393 NP_001306032 NP_001306033 NP_001306034 NP_001306035 NP_002536 NP_002536.1 n/a Location (UCSC) Chr 11: 132.41 – 133.53 Mb Chr 9: 27.79 – 28.93 Mb PubMed search [3] [4]
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This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily. The encoded protein is localized in the cell membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Two transcript variants encoding different isoforms have been found for this gene.^[6]