OmpA-like transmembrane domain
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| OmpA-like transmembrane domain | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
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| Identifiers | |||||||||||
| Symbol | OmpA_membrane | ||||||||||
| Pfam | PF01389 | ||||||||||
| Pfam clan | CL0193 | ||||||||||
| InterPro | IPR000498 | ||||||||||
| PROSITE | PDOC00819 | ||||||||||
| SCOP2 | 1bxw / SCOPe / SUPFAM | ||||||||||
| TCDB | 1.B.6 | ||||||||||
| OPM superfamily | 26 | ||||||||||
| OPM protein | 1qjp | ||||||||||
| |||||||||||
OmpA-like transmembrane domain is an evolutionarily conserved domain of bacterial outer membrane proteins. This domain consists of an eight-stranded beta barrel.[1] OmpA is the predominant cell surface antigen in enterobacteria found in about 100,000 copies per cell.[2] The expression of OmpA is tightly regulated by a variety of mechanisms. One mechanism by which OmpA expression is regulated in Vibrio species is by an antisense non-coding RNA called VrrA.[3]
The structure consists of an eight-stranded Up-And-Down Beta-Barrel. The strands are connected by four extracellular loops and three intracellular turns.[4]
