Open Notebook Science Challenge

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PCA Chemical Space for Ethanol
Descriptor Chemical Space for THF: ALOGP vs. MW

The Open Notebook Science Challenge is a crowdsourcing research project which collects measurements of the non-aqueous solubility of organic compounds and publishes these as open data; findings are reported in an open notebook science manner. Although anyone may contribute research data, the competition is only open to post-secondary students in the US and UK.

The challenge in turn forms part of the UsefulChem project, an ongoing open notebook science effort to synthesize and screen potential new anti-malarial drugs.[1] Data from the Solubility Challenge will be used to build predictive computational models of solubility for use in optimising syntheses.[2]

The challenge began on September 28, 2008[3] and, as of February 2014, involves researchers and their students from at least 4 different institutions[4] and has resulted in the acquisition of over 7672 solubility measurements.[5]

To encourage participation, each month an award[6] is given to the student who does, in the opinion of the judges,[7] the best work. In order to participate, students have to be a US or UK resident.[8] The award is a US$500 cash prize. The first three winners also received a year's subscription to the journal Nature. The awards are sponsored by Submeta[9] and Nature.

Request an experiment

As well as concentrating on compounds related to the Ugi reaction, the ONSchallenge allows anyone to request a solubility measurement experiment.[10]

Chemical donations

References

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