Opheline kinase
From Wikipedia, the free encyclopedia
Opheline kinase (EC 2.7.3.7) is an enzyme that catalyzes the reversible chemical reaction
| Opheline kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.3.7 | ||||||||
| CAS no. | 37278-15-2 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme characterised from the marine annelid, Ophelia neglecta converts guanidinoethyl methyl phosphate (opheline) to the phosphagen, N'-phosphoguanidinoethyl methylphosphate, by transferring a phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP).[1] Unlike similar kinases such as lombricine kinase, the enzyme can phosphorylate a wider range of substrates including lombricine and taurocyamine.[2]
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a nitrogenous group as acceptor. The systematic name of this enzyme class is ATP:guanidinoethyl-methyl-phosphate phosphotransferase.[3]
