Opine dehydrogenase
From Wikipedia, the free encyclopedia
Opine dehydrogenase (EC 1.5.1.28) is an enzyme that catalyzes several chemical reactions involving a class of molecules called opines.[1][2] An example is:
-2-((R)-1-carboxyethylamino)pentanoic_acid.svg)
| Opine dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.5.1.28 | ||||||||
| CAS no. | 108281-02-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The three substrates of this enzyme are an opine such as (2S)-2-[(R)-1-carboxyethylamino]pentanoic acid (1), oxidised nicotinamide adenine dinucleotide (NAD+), and water. When acting in the forward direction, the products in this example are L-norvaline, reduced NADH, pyruvic acid and a proton.[3][4]
The enzyme can also catalyse reactions that make opines by adding a molecule of pyruvic acid or other keto acids to L-amino acids. This includes making derivatives of L-methionine, L-isoleucine, L-valine, and L-phenylalanine.[2]
