Ordesekimab
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Monoclonal antibody
Ordesekimab is an anti-interleukin 15 monoclonal antibody developed by Amgen to treat refractory celiac disease.[1][2][3][4]
- ↑ Cellier, Christophe; Bouma, Gerd; van Gils, Tom; Khater, Sherine; Malamut, Georgia; Crespo, Laura; Collin, Pekka; Green, Peter H R; Crowe, Sheila E; Tsuji, Wayne; Butz, Eric; Cerf-Bensussan, Nadine; Macintyre, Elizabeth; Parnes, Jane R; Leon, Francisco; Hermine, Olivier; Mulder, Chris J; Jabri, Bana; Murray, Joseph; DiMarino, Anthony; Kelly, Ciaran P; Byrnes, Valerie; Sanders, David; Lundin, Knut EA; Schumann, Michael; Bontkes, Hetty; Meresse, Bertrand; Roy Ariño, Garbiñe; Bhagat, Govind; Viiri, Keijo; Rounioja, Samuli; Bui, Jack; Perez Maseda, Raquel; García-Hoz, Carlota; Trinquand, Amelie; Vlad, George; Hadjivassiliou, Marios; Azizi, Michel; Blanchard, Anne; Llewellyn, Beth; Palmer, Ashleigh; Raymond, Ralph (December 2019). "Safety and efficacy of AMG 714 in patients with type 2 refractory coeliac disease: a phase 2a, randomised, double-blind, placebo-controlled, parallel-group study" (PDF). The Lancet Gastroenterology & Hepatology. 4 (12): 960–970. doi:10.1016/S2468-1253(19)30265-1. PMID 31494097.
- ↑ Lähdeaho, Marja-Leena; Scheinin, Mika; Vuotikka, Pekka; Taavela, Juha; Popp, Alina; Laukkarinen, Johanna; Koffert, Jukka; Koivurova, Olli-Pekka; Pesu, Marko; Kivelä, Laura; Lovró, Zsófia; Keisala, Joni; Isola, Jorma; Parnes, Jane R; Leon, Francisco; Mäki, Markku (December 2019). "Safety and efficacy of AMG 714 in adults with coeliac disease exposed to gluten challenge: a phase 2a, randomised, double-blind, placebo-controlled study". The Lancet Gastroenterology & Hepatology. 4 (12): 948–959. doi:10.1016/S2468-1253(19)30264-X.
- ↑ Wei, Yu-Ling; Wegesser, Teresa; Kuhns, Scott; Werner, Jonathan; Lebrec, Hervé; Wang, Xiaoting (31 December 2022). "Strategies to evaluate potential effector function of glycan variants: A case study of ordesekimab (AMG 714 or PRV-015)" (PDF). Journal of Immunotoxicology. 19 (1): 109–116. doi:10.1080/1547691X.2022.2113841. PMID 36083248.
- ↑ Ciccocioppo, Rachele; Caprnda, Martin; Kruzliak, Peter (December 2019). "Blocking interleukin 15: a light at the end of the tunnel?". The Lancet Gastroenterology & Hepatology. 4 (12): 896–898. doi:10.1016/S2468-1253(19)30293-6. PMID 31494099.
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