Org 28611

Org 28611 (SCH-900,111) is a drug developed by Organon International which acts as a potent cannabinoid receptor full agonist at both the CB₁ and CB₂ receptors. It was developed with the aim of finding a water-soluble cannabinoid agonist suitable for intravenous use as an analgesic,^[1] and while it achieved this aim and has progressed as far as Phase II clinical trials in humans as both a sedative and an analgesic, results against the comparison drugs (midazolam and morphine respectively) were not particularly favourable in initial testing.^[2][3]

Legal status

• CA: Schedule II
• DE: NpSG (Industrial and scientific use only)
• UK: Under Psychoactive Substances Act

CAS Number

• 639068-99-8 ^N

PubChem CID

• 10091392

ChemSpider

• 8266929 ^Y

Quick facts Legal status, Identifiers ...

Org 28611

Legal status
Legal status	CA: Schedule II DE: NpSG (Industrial and scientific use only) UK: Under Psychoactive Substances Act
Identifiers
IUPAC name [1-(cyclohexylmethyl)-7-methoxyindol-3-yl]-[(3S)-3,4-dimethylpiperazin-1-yl]methanone
CAS Number	639068-99-8 N
PubChem CID	10091392
ChemSpider	8266929 Y
UNII	1U7V49NTQG
ChEMBL	ChEMBL1209709 Y
CompTox Dashboard (EPA)	DTXSID301029650
Chemical and physical data
Formula	C23H33N3O2
Molar mass	383.536 g·mol−1
3D model (JSmol)	Interactive image
SMILES COc3cccc(c13)c(C(=O)N(CC2C)CCN2C)cn1CC4CCCCC4
InChI InChI=1S/C23H33N3O2/c1-17-14-25(13-12-24(17)2)23(27)20-16-26(15-18-8-5-4-6-9-18)22-19(20)10-7-11-21(22)28-3/h7,10-11,16-18H,4-6,8-9,12-15H2,1-3H3/t17-/m0/s1 Y Key:ONXJNAIZJKLJGA-KRWDZBQOSA-N Y
NY (what is this?)  (verify)

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