Oritsemeyiwa Eyesan began her career in the banking industry in 1989, serving as a branch manager at the defunct People's Bank of Nigeria until 1991. She later joined the defunct Gulf Bank of Nigeria in September 1991 as a treasury officer.[5]
In 1993, she joined NNPC as a material traffic officer. Between July 2019 and November 2022, she worked as the Group General Manager, Corporate Planning.[6] In November 2022, she was appointed Chief Strategy Officer following the transformation of NNPC from a state-owned oil and gas business to a commercialised limited liability company operating under Nigeria's Companies and Allied Matters Act (CAMA).[7] In her role as Chief Strategy Officer, Eyesan created the company's sustainability framework, ensuring process and cost efficiency at a time the organisation was experiencing structural changes.[8]
Eyesan was appointed executive vice president on 17 September 2023. She oversaw NNPC's oil and gas development, exploration and production activities.[9] During her term, she reduced the contracting cycle from 300 days to 180 days, enabling an optimal operational environment for International Oil Companies (IOC) and joint venture partnerships, a move that contributed to the increase in oil production to 1.7 million barrels per day.[10]
She held the role until November 2024 when she was replaced by Udobong Ntia, following her retirement from NNPC.[11][12][13]
After Gbenga Komolafe stepped down as Commission Chief Executive of the NUPRC on 17 December 2025, Eyesan was nominated by Nigeria's President, Bola Ahmed Tinubu, to replace him.[14][15][16] Her nomination received attention from professional and interest groups nationwide, including the Women in Energy Network (WIEN)[17] and the Itsekiri Liberation Frontiers (ILF).[18][19]
On 18 December 2025, Eyesan appeared before a Nigerian Senate committee led by Senator Kawu Sumaila for screening.[20] Oritsemeyiwa Eyesan's appointment was confirmed by the senate on 19 December 2025.[21][22]
