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Oxalate oxidase

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In enzymology, oxalate oxidase (EC 1.2.3.4) is an oxalate degrading enzyme that catalyzes the chemical reaction:

2D representation of the chemical structure of oxalic acid .
oxalic acid
 
O2
H2O2
Reversible left-right reaction arrow with minor forward substrate(s) from top left, minor forward product(s) to top right, minor reverse substrate(s) from bottom right and minor reverse product(s) to bottom left
O2
H2O2
 
2 CO2
 
EC no.1.2.3.4
CAS no.9031-79-2
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oxalate oxidase
Oxalate oxidase 1 dimer, Barley
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EC no.1.2.3.4
CAS no.9031-79-2
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The two substrates of this enzyme are oxalic acid and oxygen. Its products are carbon dioxide and hydrogen peroxide.[1][2][3]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with oxygen as acceptor. The systematic name of this enzyme class is oxalate:oxygen oxidoreductase. Other names in common use include aero-oxalo dehydrogenase, and oxalic acid oxidase. This enzyme participates in glyoxylate and dicarboxylate metabolism. It uses Manganese as a cofactor.[4]

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1FI2​, PDB: 2ET1​, PDB: 2ET7​, and PDB: 2ETE​.

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