Oxetacaine

Oxetacaine (INN, also known as oxethazaine) is a potent local anesthetic. It is administered orally (usually in combination with an antacid) for the relief of pain associated with peptic ulcer disease or esophagitis. It is also used topically in the management of hemorrhoid pain. Oral oxetacaine preparations are available in several countries, including India, South Africa, Japan, Taiwan and Brazil, but not the United States. Unlike most local anesthetics, oxetacaine does not break down under strongly acidic conditions.^[1]

Routes of
administrationOral, topical

ATC code

• C05AD06 (WHO)

Elimination half-life1 hour

CAS Number

• 126-27-2 ^N

Quick facts Clinical data, Routes ofadministration ...

Oxetacaine

Clinical data
Routes of administration	Oral, topical
ATC code	C05AD06 (WHO)
Pharmacokinetic data
Elimination half-life	1 hour
Identifiers
IUPAC name 2,2'-(2-hydroxyethylimino)bis [N-(1,1-dimethyl-2- phenylethyl)-N-methylacetamide]
CAS Number	126-27-2 N
PubChem CID	4621
ChemSpider	4460 Y
UNII	IP8QT76V17
KEGG	D01152 Y
ChEMBL	ChEMBL127592 Y
CompTox Dashboard (EPA)	DTXSID0025818
ECHA InfoCard	100.004.346
Chemical and physical data
Formula	C28H41N3O3
Molar mass	467.654 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(N(C(C)(C)Cc1ccccc1)C)CN(CCO)CC(=O)N(C(Cc2ccccc2)(C)C)C
InChI InChI=1S/C28H41N3O3/c1-27(2,19-23-13-9-7-10-14-23)29(5)25(33)21-31(17-18-32)22-26(34)30(6)28(3,4)20-24-15-11-8-12-16-24/h7-16,32H,17-22H2,1-6H3 Y Key:FTLDJPRFCGDUFH-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

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It is known to produce mephentermine and phentermine as metabolites.^[2][3]