OxyS RNA
From Wikipedia, the free encyclopedia
| OxyS RNA | |
|---|---|
 Predicted secondary structure and sequence conservation of OxyS | |
| Identifiers | |
| Symbol | OxyS |
| Rfam | RF00035 |
| Other data | |
| RNA type | Gene; sRNA |
| Domain | Bacteria |
| SO | SO:0000384 |
| PDB structures | PDBe |
OxyS RNA is a small non-coding RNA which is induced in response to oxidative stress in Escherichia coli. This RNA acts as a global regulator to activate or repress the expression of as many as 40 genes, by an antisense mechanism, including the fhlA-encoded transcriptional activator and the rpoS-encoded sigma(s) subunit of RNA polymerase.[1] OxyS is bound by the Hfq protein, that increases the OxyS RNA interaction with its target messages.[2][3] Binding to Hfq alters the conformation of OxyS.[4] The 109 nucleotide RNA is thought to be composed of three stem-loops.
