P-1075
Pharmaceutical compound
From Wikipedia, the free encyclopedia
P-1075 is an ATP-sensitive potassium channel opener which was under development for the treatment of androgenic alopecia (pattern hair loss), arrhythmias, and ischemic heart disorders but was never marketed.[1][2][3][4][5] It has been found to stimulate cultured hair follicles and to promote hair growth in balding stump-tailed macaques.[3][4][5] The drug was being developed by AstraZeneca and LEO Pharma.[1][2] It reached phase 2 clinical trials for alopecia and the preclinical research stage of development for arrhythmia and ischemic heart disorders prior to the discontinuation of its development by 2000.[1][2] In terms of chemical structure, P-1075 is a guanidine derivative and a more potent analogue of pinacidil.[3]
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| Other names | P1075 |
| Drug class | ATP-sensitive potassium channel opener; Vasodilator; Antihypertensive agent |
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| ECHA InfoCard | 100.217.104 |
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| Formula | C12H17N5 |
| Molar mass | 231.303 g·mol−1 |
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