PAQR3

AliasesPAQR3, RKTG, progestin and adipoQ receptor family member 3

External IDsOMIM: 614577; MGI: 2679683; HomoloGene: 71077; GeneCards: PAQR3; OMA:PAQR3 - orthologs

Chr.Chromosome 4 (human)^[1]

End78,939,438 bp^[1]

PAQR3
Identifiers
Aliases	PAQR3, RKTG, progestin and adipoQ receptor family member 3
External IDs	OMIM: 614577; MGI: 2679683; HomoloGene: 71077; GeneCards: PAQR3; OMA:PAQR3 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q21.21 Start 78,887,127 bp[1] End 78,939,438 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E3 Start 97,230,188 bp[2] End 97,259,455 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm jejunal mucosa right testis left testis ganglionic eminence testicle skin of thigh ventricular zone Epithelium of choroid plexus gonad Top expressed in ganglionic eminence lens Mesencephalon hippocampus proper rhombencephalon dentate gyrus of hippocampal formation granule cell striatum of neuraxis Cerebellum neural tube spermatocyte More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding signaling receptor activity Cellular component integral component of membrane Golgi apparatus membrane Golgi membrane Biological process negative regulation of protein phosphorylation negative regulation of neuron projection development MAPK cascade negative regulation of MAP kinase activity negative regulation of peptidyl-serine phosphorylation protein localization to Golgi apparatus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 152559 231474 Ensembl ENSG00000163291 ENSMUSG00000055725 UniProt Q6TCH7 Q6TCG8 RefSeq (mRNA) NM_001040202 NM_177453 NM_001350105 NM_001350106 NM_198422 NM_001359910 NM_001359913 RefSeq (protein) NP_001035292 NP_001337034 NP_001337035 NP_940814 NP_001346839 NP_001346842 Location (UCSC) Chr 4: 78.89 – 78.94 Mb Chr 5: 97.23 – 97.26 Mb PubMed search [3] [4]
Wikidata
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Progestin and adipoQ receptor family member 3 (PAQR3), or Raf Kinase Trapping to Golgi apparatus (RKTG) is a protein that in humans is encoded by the PAQR3 gene.^[5] It is a member of the progestin and adipoQ receptor (PAQR) family.^[6] PAQR3 is predicted to have seven transmembrane helices and to be localized to the Golgi Apparatus.^[7][8] It functions as a tumor suppressor by negatively regulating tumor cell proliferation and migration by inhibiting Raf kinase and AKT pathway.^{[9][10][11][12][13]} PAQR3 was also shown to modulate cholesterol homeostasis by anchoring the SCAP/SREBP complex to the Golgi under cholesterol depletion conditions.^[14]