PASTA domain
Protein domain
From Wikipedia, the free encyclopedia
The PASTA domain is a small protein domain that can bind to the beta-lactam ring portion of various β-lactam antibiotics.[1] The domain was initially discovered in 2002 by Yeats and colleagues as a region of sequence similarity found in penicillin binding proteins and PknB-like kinases found in some bacteria. The name is an acronym derived from PBP and Serine/Threonine kinase Associated domain.
| PASTA domain | |||||||
|---|---|---|---|---|---|---|---|
Cartoon representation of PASTA domain from Staphylococcus aureus. PDB entry 3m9g | |||||||
| Identifiers | |||||||
| Symbol | PASTA | ||||||
| Pfam | PF03793 | ||||||
| InterPro | IPR005543 | ||||||
| SMART | PASTA | ||||||
| PROSITE | PDOC51178 | ||||||
| SCOP2 | 1rp5 / SCOPe / SUPFAM | ||||||
| CDD | cd06573 | ||||||
| |||||||
Structure
The PASTA domain adopts a structure composed of an alpha-helix followed by three beta strands. Recent structural studies show that the extracellular region of PknB (protein kinase B) that is composed of four PASTA domains shows a linear arrangement of the domains.[2]
Species distribution
PASTA domains are found in a variety of bacterial species including gram-positive Bacillota and Actinomycetota.