PBK (gene)

AliasesPBK, CT84, HEL164, Nori-3, SPK, TOPK, PDZ binding kinase

External IDsOMIM: 611210; MGI: 1289156; HomoloGene: 32415; GeneCards: PBK; OMA:PBK - orthologs

Chr.Chromosome 8 (human)^[1]

End27,838,082 bp^[1]

PBK
Identifiers
Aliases	PBK, CT84, HEL164, Nori-3, SPK, TOPK, PDZ binding kinase
External IDs	OMIM: 611210; MGI: 1289156; HomoloGene: 32415; GeneCards: PBK; OMA:PBK - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.1 Start 27,809,624 bp[1] End 27,838,082 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 D1|14 34.36 cM Start 66,043,286 bp[2] End 66,055,271 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone sperm ganglionic eminence gonad left testis right testis secondary oocyte testicle mucosa of transverse colon rectum Top expressed in spermatocyte medial ganglionic eminence superior cervical ganglion seminiferous tubule endocardial cushion Paneth cell migratory enteric neural crest cell ventricular zone renal corpuscle otic vesicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function kinase activity transferase activity nucleotide binding protein serine/threonine kinase activity protein kinase activity protein binding ATP binding Cellular component nucleus Biological process cellular response to UV negative regulation of protein phosphorylation protein phosphorylation negative regulation of stress-activated MAPK cascade negative regulation of inflammatory response phosphorylation negative regulation of proteasomal ubiquitin-dependent protein catabolic process mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55872 52033 Ensembl 55872 ENSMUSG00000022033 UniProt Q96KB5 Q9JJ78 RefSeq (mRNA) NM_001278945 NM_018492 NM_001363040 NM_023209 RefSeq (protein) NP_001265874 NP_060962 NP_001349969 NP_075698 Location (UCSC) Chr 8: 27.81 – 27.84 Mb Chr 14: 66.04 – 66.06 Mb PubMed search [3] [4]
Wikidata
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Lymphokine-activated killer T-cell-originated protein kinase is an enzyme that in humans is encoded by the PBK gene.^[5][6][7]

The protein encoded by this gene is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.^[7]