PDE1A

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A is an enzyme that in humans is encoded by the PDE1A gene.^[5][6][7]

AliasesPDE1A, CAM-PDE-1A, HCAM-1, HCAM1, HSphosphodiesterase 1A, CAM-PDE 1A

External IDsOMIM: 171890; MGI: 1201792; GeneCards: PDE1A

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 2 (human)^[1]

Quick facts Identifiers, Aliases ...

PDE1A
Identifiers
Aliases	PDE1A, CAM-PDE-1A, HCAM-1, HCAM1, HSphosphodiesterase 1A, CAM-PDE 1A
External IDs	OMIM: 171890; MGI: 1201792; GeneCards: PDE1A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LXQ
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 3.1.4.17 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q32.1 Start 182,139,968 bp[1] End 182,523,359 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C3 Start 79,664,797 bp[2] End 79,959,802 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm Brodmann area 23 buccal mucosa cell middle temporal gyrus renal medulla entorhinal cortex parietal lobe postcentral gyrus superior frontal gyrus cerebellar cortex Top expressed in spermatid dentate gyrus of hippocampal formation granule cell seminiferous tubule right kidney primary visual cortex superior frontal gyrus subiculum anterior amygdaloid area primary motor cortex Region I of hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoric diester hydrolase activity calmodulin-dependent cyclic-nucleotide phosphodiesterase activity hydrolase activity 3',5'-cyclic-nucleotide phosphodiesterase activity metal ion binding calmodulin binding calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity cGMP binding 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-GMP phosphodiesterase activity Cellular component cytosol cytoplasm nucleus soma Biological process cGMP catabolic process cAMP catabolic process signal transduction regulation of smooth muscle cell apoptotic process regulation of smooth muscle cell proliferation G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 5136 18573 Ensembl ENSG00000115252 ENSMUSG00000059173 UniProt P54750 Q9Y633 Q61481 RefSeq (mRNA) NM_001003683 NM_001258312 NM_001258313 NM_001258314 NM_005019 NM_001363871 NM_001395258 NM_001395259 NM_001395260 NM_001395261 NM_001395262 NM_001395263 NM_001395264 NM_001395265 NM_001395266 NM_001395267 NM_001395268 NM_001395269 NM_001009978 NM_001009979 NM_001159582 NM_016744 NM_001355140 NM_001355141 NM_001355142 NM_001355143 NM_001355144 RefSeq (protein) NP_001003683 NP_001245241 NP_001245242 NP_001245243 NP_005010 NP_001350800 NP_001245241.1 NP_001009978 NP_001009979 NP_001153054 NP_058024 NP_001342069 NP_001342070 NP_001342071 NP_001342073 Location (UCSC) Chr 2: 182.14 – 182.52 Mb Chr 2: 79.66 – 79.96 Mb PubMed search [3] [4]
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